Investigating the Role of Geospatial Technologies as a Supplement to Environmental Education: Development of an Environmental Data Collection Application and Its Implementation in the Classroom

Informal STEM (Science, Technology, Engineering, and Math) education refers to science learning that takes place in a non-traditional setting, such as a museum, a library, and outside a classroom, based on the methods different from the traditional pen-to-paper style of classroom learning. A critical component of Informal STEM education is to ensure student understanding and using available technologies to better analyze and convey scientific data, particularly for the data that are spatial in nature. Combining mobile technologies with geographic information systems (GIS) in field data collection provides unique opportunities for students to feel stimulated and engaged in what they are learning and to take ownership of their own learning process.In this thesis, I developed a publicly available and open access data collection application and investigated its impacts on students’ engagement and perception of the incorporation of technology in their learning within the environmental science curricula. The analyses of pre- and post-surveys indicate that the inclusion of geospatial technologies as a part of curricula can significantly boost students’ engagement by allowing the opportunities to 1) take the lead on their own research, 2) view field data in real-time as opposed to looking at a database in hindsight, and 3) view and analyze multiscale data as it is presented during field analysis. The findings of this study are consistent with previous studies, suggesting a strong correlation between the inclusion of geospatial technologies as a part of curricula and student engagement and performance

Novel patterns of genome rearrangement and their association with survival in breast cancer

Representational Oligonucleotide Microarray Analysis (ROMA) detects genomic amplifications and deletions with boundaries defined at a resolution of ∼50 kb. We have used this technique to examine 243 breast tumors from two separate studies for which detailed clinical data were available. The very high resolution of this technology has enabled us to identify three characteristic patterns of genomic copy number variation in diploid tumors and to measure correlations with patient survival. One of these patterns is characterized by multiple closely spaced amplicons, or “firestorms,” limited to single chromosome arms. These multiple amplifications are highly correlated with aggressive disease and poor survival even when the rest of the genome is relatively quiet. Analysis of a selected subset of clinical material suggests that a simple genomic calculation, based on the number and proximity of genomic alterations, correlates with life-table estimates of the probability of overall survival in patients with primary breast cancer. Based on this sample, we generate the working hypothesis that copy number profiling might provide information useful in making clinical decisions, especially regarding the use or not of systemic therapies (hormonal therapy, chemotherapy), in the management of operable primary breast cancer with ostensibly good prognosis, for example, small, node-negative, hormone-receptor-positive diploid cases

Political Control versus Bureaucratic Values: Reframing the Debate

The literature on political control of bureaucracy reveals that bureaucracies are highly responsive to political forces. This paper argues that the political control literature misses evidence from other academic literature that bears directly on this phenomenon. Specifically, researchers need to consider the values of the bureaucracy in any effort to assess the degree of political control. An empirical test is presented using a data set from public education. Results show bureaucratic values to be far more influential in explaining bureaucratic outputs and outcomes than political factors. These findings suggest that a reinterpretation of previous empirical research is urgently in order

Snowmass 2021 CMB-S4 White Paper

This Snowmass 2021 White Paper describes the Cosmic Microwave Background Stage 4 project CMB-S4, which is designed to cross critical thresholds in our understanding of the origin and evolution of the Universe, from the highest energies at the dawn of time through the growth of structure to the present day. We provide an overview of the science case, the technical design, and project plan

Snowmass 2021 CMB-S4 White Paper

This Snowmass 2021 White Paper describes the Cosmic Microwave Background Stage 4 project CMB-S4, which is designed to cross critical thresholds in our understanding of the origin and evolution of the Universe, from the highest energies at the dawn of time through the growth of structure to the present day. We provide an overview of the science case, the technical design, and project plan